Intended Use: Consensus-Based Reference Method 1 Purpose AOAC SMPRs describe the minimum recommended performance characteristics to be used during the evaluation of a method. The evaluation may be an on-site verification, a single-laboratory validation, or a multi-site collaborative study. SMPRs are written and adopted by AOAC stakeholder panels composed of representatives from the industry, regulatory organizations, contract laboratories, test kit manufacturers, and academic institutions.

AOAC SMPRs are used by AOAC expert review panels in their evaluation of validation study data for the method being considered for Performance Tested Methods SM or AOAC Official Methods of Analysis SM and can be used as acceptance criteria for verification at user laboratories. 2 Applicability Method, or a suite of methods, to identify and quantify selected pesticide residues (Table 1) in dried cannabis plant materials. 3 Analytical Technique Any analytical technique(s) that measures the analytes of interest and meets the following method performance requirements is/are acceptable. More than one analytical technique may be needed. 4 Definitions Dried plant material.-Dried whole or milled flower plant material from Cannabis sp. and its hybrids. Limit of quantitation (LOQ).-Minimum concentration or mass of analyte in a given matrix that can be reported as a quantitative result. Multiresidue method (MRM).-A method able to distinguish, followed by identification and/or quantification of, more than one pesticide residue in one analysis.

Parts per million (PPM).-Also expressed as milligrams of analyte per kilogram of dried plant materials (as received). Quantitative method.-Method of analysis where response is the amount of the analyte measured either directly (enumeration in a mass or a volume) or indirectly (color, absorbance, impedance, etc.) in a certain amount of sample. Recovery.-Fraction or percentage of spiked analyte that is recovered when the test sample is analyzed using the entire method. Repeatability.-Variation arising when all efforts are made to keep conditions constant by using the same instrument and operator and repeating during a short time period. Expressed as the repeatability standard deviation (SD r); or % repeatability relative standard deviation (%RSD r). Reproducibility.-Standard deviation or relative standard deviation calculated from among-laboratory data. Expressed as the reproducibility standard deviation (SD R); or % reproducibility relative standard deviation (%RSD R). 5 Method Performance Requirements

Sankar, Kiruba. (2023). Standard Method Performance Requirements (SMPRs ® ) for Identification and Quantitation of Selected Pesticide Residues in Dried Cannabis Materials.

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