Cannabis sativa L., also called hemp, is a plant of the Cannabaceae family that originates from central and south-west Asia. Over time, the genetic diversity of cannabis has expanded, leading to the emergence of numerousdistinct genotypes characterized by varied phenotypes and a wide range of secondary metabolites.
These metabo-lites exhibit diverse biological properties and are utilized in human medicine and the pharmaceutical industry.Cannabis sativa L . includes different genetically distinct biotypes, notably industrial hemp and recreationalcannabis. It has been used for its fiber, oil, food, and medicinal properties, as well as for recreational and religiouspurposes. It contains various bioactive substances such as alkaloids, flavonoids, terpenoids, and cannabinoids. Theconcentrations of these secondary metabolites vary significantly depending on the plant genotype and environmen-tal factors, whether abiotic or biotic. Microorganisms associated with Cannabis sativa L., whether residing on thesurface, within tissues, or in cultivated soils, exhibit significant genetic diversity. They provide benefits, such aspromoting plant growth, protecting against pathogens, improving mineral absorption, and influencing the produc-tion of secondary metabolites. The use of beneficial microorganisms, such as PGPR bacteria, endophytic fungi, ortheir bioactive molecules, could play a key role in enhancing cannabinoid production in cannabis plants. Althoughthe chemistry of cannabis has been extensively studied, further research is needed to understand the influence ofbiotic and abiotic factors on the variation in synthesized cannabinoid levels.
This review provides a comprehensiveoverview of Cannabis sativa L., specifically focusing on its associated microorganisms and their interactions withthe plant. It also explores opportunities for the optimal utilization of this plant, particularly focusing on its micro-organisms, to enhance growth, protect against bio-aggressors, and promote cannabinoid biosynthesis. This paperalso reviews current investigations and suggests various opportunities for further research perspectives.Keywords: Cannabis plant, cannabinoid, associated microorganisms, genotype, biostimulant, biopesticide.
Laanaya, Jihane & Msairi, Soukaina & Touhami, Amina & Douira, Allal. (2025). Unlocking the potential of Cannabis sativa L. – interactions with microorganisms for growth, protection, and cannabinoid production: A review. Ecological Engineering & Environmental Technology. 26. 364-375. 10.12912/27197050/209642.
Source: Research Gate
