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Weizmann Institute scientists unveil "parallel evolution of cannabinoid biosynthesis"

In a disruptive study article published in Nature Plants leading scientific journal, and followed by a special review in the journal's News & Views, Weizmann Institute scientists revealed a step-by-step production of cannabinoids in the Helichrysum umbraculigerum plant. The study, led by Dr. Shirley (Paula) Berman, in the Prof. Asaph Aharoni lab of the Weizmann Institute Plant and Environmental Sciences department, reveals a completely alternative non-cannabis plant-derived production system, which is capable of highly efficient and flawless end-to-end cannabinoid biosynthesis, according to the study. "This exclusive non-cannabis alternative novel IP was recently successfully utilized and implemented by Xinteza to its super-efficient microbial cannabinoid bio-production newly developed proprietary platform," the Xinteza team says.

This newly discovered alternative gene pool includes a novel prenyltransferase enzyme, featuring superior kinetics and improved flexibility to solve major bottlenecks hindering cannabinoid biosynthesis. Furthermore, as previously reported, this alternative non-cannabis plant-derived system also includes a novel sub-set of cannabinoid-glycosylation enzymes and genes, enabling the biosynthesis of true water-soluble cannabinoids to revolutionize beverages, cosmetics, and pharma.

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